Sr. Medical Director

Step into a high-impact clinical leadership role where you will help shape early-stage oncology development, influence pivotal decisions on trial design and safety, and bring promising targeted therapies closer to patients who need better options. This opportunity offers the chance to work with a nimble, science-driven team where your medical judgement and clinical development expertise will be highly visible and valued.

Our client is a clinical-stage biopharmaceutical company focused on small-molecule drug development using a precision-medicine approach, with an emphasis on addressing unmet needs in oncology. They are hiring a Medical Director / Senior Medical Director, Oncology Clinical Development (Early Stage) to provide medical leadership across early-phase studies and contribute to broader clinical development strategy.

Role Summary

You will serve as the Study Responsible Physician for one or more early development oncology studies, partnering closely with cross-functional teams (clinical operations, biostatistics, regulatory, translational, and more) and engaging with external investigators and key stakeholders. This is a remote (USA) role with up to ~30% travel for key conferences and essential in-person meetings. Occasional on-call or out-of-hours work may be needed based on study demands.

Key Responsibilities

• Lead medical oversight as Study Responsible Physician across assigned early-phase clinical studies
• Drive trial design, execution, and interpretation of safety and proof-of-concept data
• Deliver ongoing medical monitoring, including safety review and benefit–risk evaluation
• Partner cross-functionally to ensure high-quality, timely study delivery
• Build strong relationships with investigators, cooperative groups, and key opinion leaders
• Support creation and review of protocols, amendments, investigator brochures, ICFs, and clinical study reports
• Present clinical data to internal governance and external scientific audiences
• Ensure high standards for patient safety, scientific integrity, and GCP-aligned execution
• Contribute to regulatory submissions/responses and publication activities

Experience & Requirements

• MD (or equivalent medical degree) required
• Board certification/eligibility in Hematology/Oncology (or related specialty) preferred
• Hematology/oncology clinical development experience:
  • Medical Director: 3+ years
  • Senior Medical Director: 5–8+ years
• Proven experience running Phase 1/2 studies with minimal supervision
• Strong knowledge of trial design, safety review, medical monitoring, data interpretation, regulatory expectations, and GCP
• Experience supporting key documents (e.g., protocols, IBs, CSRs, and regulatory materials)
• Excellent English communication and strong cross-functional leadership skills
• Ability to travel up to ~30%

Salary

This role offers a base salary between £300,000 and £350,000, depending on experience.

Apply now to be part of a growing team shaping the future of precision oncology drug development.