Director, Clinical Pharmacology

Overview

A clinical-stage life sciences organization is hiring a Director, Clinical Pharmacology to shape dosing strategy and clinical pharmacology plans across early development programs.
In this role, you’ll influence study design, interpret emerging PK/PD and exposure–response insights, and help teams make confident, data-driven development decisions.
If you enjoy partnering cross-functionally and turning complex clinical data into clear recommendations, this is a high-impact opportunity with significant visibility.

About our client

Our client is a clinical-stage life sciences organization developing innovative therapeutics to address serious unmet medical needs. Their work spans discovery through clinical development, with a focus on translating rigorous science into meaningful patient impact. This role is critical to ensuring development strategies are grounded in strong clinical pharmacology principles as programs advance.

The opportunity (Role summary)

You will provide strategic and operational clinical pharmacology leadership across multiple clinical development programs. You’ll serve as the clinical pharmacology voice on cross-functional teams, partnering closely with functions such as clinical development, clinical operations, biostatistics, biomarkers, bioanalysis, nonclinical pharmacology, toxicology, and regulatory.
Work arrangement: Remote (US).
Travel: Not specified.

Key responsibilities

• Lead clinical pharmacology strategy and provide scientific input to development and study teams
• Deliver integrated interpretations of nonclinical and clinical PK/PD, exposure–response, safety, efficacy, and biomarker data
• Drive dose selection and optimization recommendations to support study design decisions
• Manage the design and oversight of clinical pharmacology studies (e.g., ADME, interaction, food-effect, bioavailability, special populations)
• Analyze and/or oversee non-compartmental PK analyses and interpretation of emerging clinical PK data
• Apply and/or oversee model-informed approaches (e.g., population PK, PK/PD, exposure–response, PBPK) as appropriate
• Author and review clinical pharmacology sections for protocols and regulatory documents; support regulatory interactions
• Partner with external vendors/consultants, ensuring quality, timelines, and deliverables
• Communicate risks, opportunities, and recommendations to stakeholders and senior leaders

What you’ll bring

• Advanced scientific degree with 8+ years (or MS with 12+ years) of relevant industry experience in clinical pharmacology and drug development
• Strong background in small-molecule development, including ADME, PK/PD, exposure–response, interaction assessments, and dose optimization
• Experience supporting early clinical development and integrating emerging data into strategy
• Hands-on experience with non-compartmental PK analysis and interpretation using industry-standard analysis tools
• Familiarity with model-informed drug development; hands-on modeling/simulation experience is a plus
• Experience contributing to regulatory submissions and working with US and global health authorities
• Strong scientific judgment, communication, and cross-functional collaboration skills