Executive Medical Director/VP, Clinical Development

Electra Therapeutics, based in South San Francisco, California, is a clinical stage biotechnology company developing therapies that target signal regulatory proteins (SIRP) for the treatment of immunological diseases and cancer. 

The Executive Medical Director/VP, Clinical Development will report to the Chief Medical Officer and serve as a key member of the clinical leadership team. This individual will provide medical leadership while remaining hands-on in early-stage clinical programs, including upcoming first-in-human studies in inflammation. They will work closely with research and translational teams to align clinical and pre-clinical priorities and may also provide clinical leadership across programs in the company’s pipeline as needed.

The ideal candidate is a board-certified rheumatologist or immunologist with demonstrated expertise in autoimmune or inflammatory diseases. This individual will bring a strong track record in early development, and a willingness to be deeply involved in the day-to-day execution of clinical trials.

KEY RESPONSIBILITIES:  

• Build upon the medical vision and clinical strategy to advance Electra’s immunology/inflammation programs, including early development and first-in-human studies, while supporting other programs across the pipeline as appropriate
• Provide clinical leadership alongside the CMO and executive leadership to define regulatory, operational, and scientific strategy for the pipeline
• Lead clinical data review, analysis, and interpretation to support patient safety and program go/no-go decisions
• Act as the medical lead and subject-matter expert for clinical studies, providing hands-on oversight as Medical Monitor to ensure patient safety and trial integrity
• Author and review clinical study protocols, investigator brochures, clinical sections of regulatory submissions, and other critical documents
• Attend clinical, scientific and investigator meetings representing Electra as a medical expert regarding drug development candidates
• Evaluate, select, and develop relationships with key opinion leaders, clinical investigators, and contract research organizations
• Provide leadership to cross-functional teams while remaining hands-on in clinical operations, regulatory, and data activities
• Ensure that clinical trials are conducted in accordance with applicable regulatory requirements and guidelines as well as a ‘patients first’ mentality

EDUCATION & PROFESSIONAL EXPERIENCE:

• MD with board certification in rheumatology or immunology strongly preferred; clinical experience practicing as a physician, preferably in rheumatology or immunology, is highly valued
• At least 5 years of biopharmaceutical industry experience in clinical development to demonstrate knowledge of all phases of drug development and at least 10 years of clinical trial experience combined (academic and biopharmaceutical industry experience).
• Demonstrated expertise in immunology, inflammation, or autoimmune diseases
• Strong hands-on experience in medical monitoring, clinical data review, and authoring/reviewing clinical documents
• Proven ability to collaborate across functions including clinical operations, regulatory affairs, translational medicine, and biostatistics
• Working knowledge of GCP, ICH, FDA, EMEA, SFDA, PMDA and other key health agency regulations and requirements to move a product to first-in-human studies and early to late-stage development
• Ability to interact and build strong relationships with external Key Opinion Leaders and industry experts in hematology
• Ability to assess the feasibility of portfolio programs and create a development plan from first-in-human to clinical proof-of-concept to BLA
• Experience working across multiple therapeutic areas and ability to provide clinical leadership beyond a primary disease focus
• Ability to operate and thrive in a fast-paced environment; demonstrated flexibility; self-starter, proactive and results-oriented with high performance standards
• Willingness to be hands-on and detail oriented while understanding the organization’s long-term goals
• Excellent interpersonal and communication skills, with ability to build strong relationships internally, externally, and with the Board of Directors

The salary range for this position is $350,000 - $380,000. Base salary compensation is determined by a range of factors, including but not limited to candidate experience, qualifications, location and more.